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Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes

Mustroph, Julian, Wagemann, Olivia, Lücht, Charlotte M., Trum, Maximilian, Hammer, Karin P., Sag, Can Martin, Lebek, Simon, Tarnowski, Daniel, Reinders, Jörg, Perbellini, Filippo, Terracciano, Cesare, Schmid, Christof, Schopka, Simon, Hilker, Michael, Zausig, York, Pabel, Steffen, Sossalla, Samuel T., Schweda, Frank, Maier, Lars S. and Wagner, Stefan (2018) Empagliflozin reduces Ca/calmodulin-dependent kinase II activity in isolated ventricular cardiomyocytes. ESC Heart Failure 5 (4), pp. 642-648.

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Date of publication of this fulltext: 24 Sep 2018 15:02

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Other URL: http://doi.org/10.1002/ehf2.12336, https://onlinelibrary.wiley.com/doi/abs/10.1002/ehf2.12336


Abstract

Aims The EMPA‐REG OUTCOME study showed reduced mortality and hospitalization due to heart failure (HF) in diabetic patients treated with empagliflozin. Overexpression and Ca2+‐dependent activation of Ca2+/calmodulin‐dependent kinase II (CaMKII) are hallmarks of HF, leading to contractile dysfunction and arrhythmias. We tested whether empagliflozin reduces CaMKII‐ activity and improves ...

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Item type:Article
Date:August 2018
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1002/ehf2.12336DOI
Keywords:Empagliflozin; Heart failure; CaMKII; Calcium; Ca leak
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37761
Owner only: item control page

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