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TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity

Riquelme, Paloma , Haarer, Jan, Kammler, Anja Nadine, Walter, Lisa , Tomiuk, S., Ahrens, Norbert , Wege, Anja K. , Goecze, Ivan, Zecher, D., Banas, Bernhard , Spang, Rainer, Fandrich, F., Lutz, M. B., Sawitzki, B., Schlitt, Hans-Jürgen , Ochando, Jordi , Geissler, Edward K. and Hutchinson, J. A. (2018) TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity. Nat Commun 9, p. 2858.

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Date of publication of this fulltext: 02 Nov 2018 13:18

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Other URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054648/


Abstract

Human regulatory macrophages (Mreg) have shown early clinical promise as a cell-based adjunct immunosuppressive therapy in solid organ transplantation. It is hypothesised that recipient CD4+ T cell responses are actively regulated through direct allorecognition of donor-derived Mregs. Here we show that human Mregs convert allogeneic CD4+ T cells to IL-10-producing, TIGIT+ FoxP3+-induced ...

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Item type:Article
Date:20 July 2018
Institutions:Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Statistische Bioinformatik (Prof. Spang)
Identification Number:
ValueType
30030423PubMed ID
10.1038/s41467-018-05167-8DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:37892
Owner only: item control page

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