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Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

Gerthofer, V., Kreutz, Marina , Renner, Kathrin, Jachnik, Birgit, Dettmer, Katja , Oefner, Peter J. , Riemenschneider, Markus J., Proescholdt, Martin A. , Vollmann-Zwerenz, Arabel, Hau, Peter and Seliger, Corinna (2018) Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma. Int J Mol Sci 19 (9).

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Date of publication of this fulltext: 02 Nov 2018 13:30

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Other URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163514/


Abstract

Glioblastoma remains a fatal diagnosis. Previous research has shown that metformin, which is an inhibitor of complex I of the respiratory chain, may inhibit some brain tumor initiating cells (BTICs), albeit at dosages that are too high for clinical use. Here, we explored whether a combined treatment of metformin and diclofenac, which is a non-steroidal anti-inflammatory drug (NSAID) shown to ...

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Item type:Article
Date:31 August 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Neurologie
Medicine > Abteilung für Neuropathologie
Identification Number:
ValueType
30200299PubMed ID
10.3390/ijms19092586DOI
Keywords:glioma, BTICs, metformin, diclofenac, lactate
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37894
Owner only: item control page

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