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Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma

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Gerthofer, V. ; Kreutz, Marina ; Renner, Kathrin ; Jachnik, Birgit ; Dettmer, Katja ; Oefner, Peter J. ; Riemenschneider, Markus J. ; Proescholdt, Martin A. ; Vollmann-Zwerenz, Arabel ; Hau, Peter ; Seliger, Corinna
Date of publication of this fulltext: 02 Nov 2018 13:30


Glioblastoma remains a fatal diagnosis. Previous research has shown that metformin, which is an inhibitor of complex I of the respiratory chain, may inhibit some brain tumor initiating cells (BTICs), albeit at dosages that are too high for clinical use. Here, we explored whether a combined treatment of metformin and diclofenac, which is a non-steroidal anti-inflammatory drug (NSAID) shown to ...


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