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Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics

Weber, Daniela, Hiergeist, Andreas , Weber, Markus, Dettmer, Katja , Wolff, Daniel, Hahn, Joachim, Herr, Wolfgang, Gessner, Andre and Holler, Ernst (2018) Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics. Clin. Infect. Dis..

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Date of publication of this fulltext: 05 Nov 2018 14:44

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Other URL: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciy711/5075542


Abstract

Background Maintaining gastrointestinal (GI) microbiome diversity plays a key role during allogeneic stem cell transplantation (ASCT), and loss of diversity correlates with acute GI graft versus host disease (GvHD) and poor outcomes. Methods In this retrospective analysis of 161 ASCT patients, we used serial analyses of urinary 3-indoxyl sulfate (3-IS) levels and GI microbiome parameters ...

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Item type:Article
Date:17 August 2018
Institutions:Medicine > Institut für Funktionelle Genomik > Lehrstuhl für Funktionelle Genomik (Prof. Oefner)
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Medicine > Lehrstuhl für Orthopädie
Identification Number:
ValueType
30124813PubMed ID
10.1093/cid/ciy711DOI
Keywords:broad-spectrum antibiotics, gut microbiome, allogeneic stem cell transplantation, acute intestinal graft versus host disease
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37896
Owner only: item control page

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