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Detrimental effect of broad-spectrum antibiotics on intestinal microbiome diversity in patients after allogeneic stem cell transplantation: Lack of commensal sparing antibiotics

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Weber, Daniela ; Hiergeist, Andreas ; Weber, Markus ; Dettmer, Katja ; Wolff, Daniel ; Hahn, Joachim ; Herr, Wolfgang ; Gessner, Andre ; Holler, Ernst
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Date of publication of this fulltext: 05 Nov 2018 14:44


Background. Maintaining gastrointestinal (GI) microbiome diversity plays a key role during allogeneic stem cell transplantation (ASCT), and loss of diversity correlates with acute GI graft versus host disease (GvHD) and poor outcomes. Methods. In this retrospective analysis of 161 ASCT patients, we used serial analyses of urinary 3-indoxyl sulfate (3-IS) levels and GI microbiome parameters within ...


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