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Assessment of urinary 3-indoxyl sulfate as a marker for gut microbiota diversity and abundance of Clostridiales

Farowski, F. ; Els, G. ; Tsakmaklis, A. ; Higgins, P. G. ; Kahlert, C. R. ; Stein-Thoeringer, C. K. ; Bobardt, J. S. ; Dettmer-Wilde, Katja ; Oefner, Peter J. ; Vehreschild, J. J. ; Vehreschild, M. J. G. T.



Abstract

Objectives: After allogeneic hematopoietic stem cell transplantation (allo-HCT), urinary levels of 3-indoxyl sulfate (3-IS) correlate with the relative abundance of bacteria from the class Clostridia (RAC), and antibiotic treatment is considered the major determinant of this outcome. A high RAC has been associated with favorable outcome after allo-HCT and protection from Clostridium difficile ...

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