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The functional consequences of sodium channel NaV 1.8 in human left ventricular hypertrophy

Ahmad, Shakil, Tirilomis, Petros, Pabel, Steffen, Dybkova, Nataliya, Hartmann, Nico, Molina, Cristina E., Tirilomis, Theodoros, Kutschka, Ingo, Frey, Norbert, Maier, Lars S., Hasenfuss, Gerd, Streckfuss-Bömeke, Katrin and Sossalla, Samuel (2018) The functional consequences of sodium channel NaV 1.8 in human left ventricular hypertrophy. ESC Heart Failure 2018, pp. 1-10.

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Date of publication of this fulltext: 07 Nov 2018 13:39

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Other URL: http://doi.org/10.1002/ehf2.12378


Abstract

Aims In hypertrophy and heart failure, the proarrhythmic persistent Na+ current (INaL) is enhanced. We aimed to investigate the electrophysiological role of neuronal sodium channel NaV1.8 in human hypertrophied myocardium. Methods and results Myocardial tissue of 24 patients suffering from symptomatic severe aortic stenosis and concomitant significant afterload‐induced hypertrophy with ...

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Item type:Article
Date:30 October 2018
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1002/ehf2.12378DOI
Keywords:Left ventricular hypertrophy; Sodium channels; Late sodium current; HFpEF; Arrhythmias; Calcium; SR-Ca2+ leak
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:37933
Owner only: item control page

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