Hepatitis E virus genotype 3 is a common finding in liver-transplanted patients undergoing liver biopsy for elevated liver enzymes with a low De Ritis ratio and suspected acute rejection: A real-world cohort

DOI to cite this document:

10.5283/epub.38244 Copy

Darstein, Felix ; Häuser, Friederike ; Straub, Beate K. ; Wenzel, Jürgen J. ; Conradi, Roland ; Mittler, Jens ; Lang, Hauke ; Galle, Peter R. ; Zimmermann, Tim

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Date of publication of this fulltext: 23 Jan 2019 15:24

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Details

Item type:	Article
Journal or Publication Title:	Clinical Transplantation
Publisher:	Wiley
Place of Publication:	HOBOKEN
Volume:	32
Number of Issue or Book Chapter:	11
Page Range:	e13411
Date:	2018
Institutions:	Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:	Value Type 10.1111/ctr.13411 DOI 30230607 PubMed ID
Keywords:	CALCINEURIN INHIBITORS; MYCOPHENOLIC-ACID; RECIPIENTS; INFECTION; CYTOMEGALOVIRUS; SURVIVAL; GERMANY; HEV; THERAPY; SAFETY;
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Partially
Item ID:	38244

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Abstract

Background Hepatitis E virus (HEV) infection is a potential reason for elevated liver enzymes after liver transplantation (LT). Our aim was to analyze a real-world cohort of LT patients, who underwent liver biopsy for elevated transaminases and suspected acute rejection, to evaluate frequency of post-transplant HEV infection. Patients Data from 160 liver biopsies were analyzed. Seventy-one ...

Abstract

Background Hepatitis E virus (HEV) infection is a potential reason for elevated liver enzymes after liver transplantation (LT). Our aim was to analyze a real-world cohort of LT patients, who underwent liver biopsy for elevated transaminases and suspected acute rejection, to evaluate frequency of post-transplant HEV infection. Patients Data from 160 liver biopsies were analyzed. Seventy-one patients were biopsied on schedule after LT without elevated liver enzymes. A subgroup of 25 patients with elevated liver enzymes and suspected rejection was chosen for further analysis. Patient demographics and data were retrieved from a clinical database, patients' charts, and reports. Results Hepatitis E virus infection was diagnosed in five of 25 patients with suspected acute rejection (20%). HEV genotype 3 was detected in three of the five HEV-infected patients. Patients with HEV infection showed higher ALT levels (P = 0.014), lower De Ritis ratio (P = 0.021), and more frequent glucocorticoid therapy (P = 0.012) compared to HEV-negative patients. Conclusion We found a rate of 20% HEV infections in LT patients undergoing liver biopsy for elevated liver enzymes and suspected acute rejection. These data indicate the necessity for HEV testing in all LT patients with elevated liver enzymes and suspected acute rejection.

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Metadata last modified: 25 Nov 2020 18:46

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