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D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells

Ugele, Ines, Cardenas-Conejo, Zugey Elizabeth, Hammon, Kathrin, Wehrstein, Monika, Bruss, Christina, Peter, Katrin, Singer, Katrin, Gottfried, Eva, Boesch, Jakob, Oefner, Peter J. , Dettmer, Katja , Renner, Kathrin and Kreutz, Marina (2019) D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells. International Journal of Molecular Sciences 20 (3), p. 742.

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Date of publication of this fulltext: 11 Feb 2019 12:49

Other URL: https://www.mdpi.com/1422-0067/20/3/742


Abstract

Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiation and activation; however, effects on human myeloid cells have not been investigated so far. In this study we analyzed the impact of D-2-HG and ...

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Item type:Article
Date:10 February 2019
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Projects:Open Access Publizieren (DFG)
Keywords:isocitrate dehydrogenase; hydroxyglutarate; dendritic cells; tumor environment; activation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38315
Owner only: item control page

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