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D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells

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Ugele, Ines ; Cardenas-Conejo, Zugey Elizabeth ; Hammon, Kathrin ; Wehrstein, Monika ; Bruss, Christina ; Peter, Katrin ; Singer, Katrin ; Gottfried, Eva ; Boesch, Jakob ; Oefner, Peter J. ; Dettmer, Katja ; Renner, Kathrin ; Kreutz, Marina
Date of publication of this fulltext: 11 Feb 2019 12:49


Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiation and activation; however, effects on human myeloid cells have not been investigated so far. In this study we analyzed the impact of D-2-HG and ...


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