| License: Creative Commons Attribution 4.0 (3MB) |
- URN to cite this document:
- urn:nbn:de:bvb:355-epub-383153
- DOI to cite this document:
- 10.5283/epub.38315
Abstract
Mutations in isocitrate dehydrogenase (IDH) or a reduced expression of L-2-hydroxyglutarate (HG)-dehydrogenase result in accumulation of D-2-HG or L-2-HG, respectively, in tumor tissues. D-2-HG and L-2-HG have been shown to affect T-cell differentiation and activation; however, effects on human myeloid cells have not been investigated so far. In this study we analyzed the impact of D-2-HG and ...

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