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Chromatin alterations during transformation of B cells by a constitutively active mutant of STAT5

Unser, Samy (2019) Chromatin alterations during transformation of B cells by a constitutively active mutant of STAT5. PhD, Universität Regensburg.

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Chromatin alterations during transformation of B cells by a constitutively active mutant of STAT5
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Date of publication of this fulltext: 15 Mar 2019 09:33

Abstract (English)

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated conditionally and transiently by external stimuli. Thereupon, STAT5 modulates the transcription of its target genes, promoting cell survival and growth. Constitutive STAT5 activity has been shown to be oncogenic in hematopoietic cells. This correlates with the acquisition of cancer hallmarks, such as ...

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Translation of the abstract (German)

Der Transkriptionsfaktor signal transducer and activator of transcription 5 (STAT5) wird von externen Stimuli zeitlich begrenzt aktiviert. Daraufhin moduliert STAT5 die Transkription seiner Zielgene und vermittelt so eine Zellüberlebens- und Zellwachstumsantwort. Konstitutive STAT5-Aktivität ist onkogen und an der Leukämie- und Lymphomentstehung aus blutbildenden Zellen beteiligt. Diese ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:15 March 2019
Referee:PD Dr. Anne Rascle
Date of exam:7 March 2019
Institutions:Medicine > Lehrstuhl für Immunologie
Keywords:STAT5 Chromatin Histone Nucleosome Cancer Oncogenesis Cis Spi2.1 c-Myc Pim-1
Dewey Decimal Classification:500 Science > 500 Natural sciences & mathematics
500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38432
Owner only: item control page

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