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Chromatin alterations during transformation of B cells by a constitutively active mutant of STAT5

URN to cite this document:
urn:nbn:de:bvb:355-epub-384326
DOI to cite this document:
10.5283/epub.38432
Unser, Samy
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License: Creative Commons Attribution 4.0
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Chromatin alterations during transformation of B cells by a constitutively active mutant of STAT5
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Date of publication of this fulltext: 15 Mar 2019 09:33


Abstract (English)

The transcription factor signal transducer and activator of transcription 5 (STAT5) is activated conditionally and transiently by external stimuli. Thereupon, STAT5 modulates the transcription of its target genes, promoting cell survival and growth. Constitutive STAT5 activity has been shown to be oncogenic in hematopoietic cells. This correlates with the acquisition of cancer hallmarks, such as ...

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Translation of the abstract (German)

Der Transkriptionsfaktor signal transducer and activator of transcription 5 (STAT5) wird von externen Stimuli zeitlich begrenzt aktiviert. Daraufhin moduliert STAT5 die Transkription seiner Zielgene und vermittelt so eine Zellüberlebens- und Zellwachstumsantwort. Konstitutive STAT5-Aktivität ist onkogen und an der Leukämie- und Lymphomentstehung aus blutbildenden Zellen beteiligt. Diese ...

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