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Hepatocyte-specific Smad7 deletion accelerates DEN-induced HCC via activation of STAT3 signaling in mice

Feng, T. ; Dzieran, J. ; Yuan, X. ; Dropmann, A. ; Maass, T. ; Teufel, A. ; Marhenke, S. ; Gaiser, T. ; Rückert, F. ; Kleiter, I. ; Kanzler, S. ; Ebert, M. P. ; Vogel, A. ; ten Dijke, P. ; Dooley, S. ; Meindl-Beinker, N. M.


TGF-beta signaling in liver cells has variant roles in the dynamics of liver diseases, including hepatocellular carcinoma (HCC). We previously found a correlation of high levels of the important endogenous negative TGF-beta signaling regulator SMAD7 with better clinical outcome in HCC patients. However, the underlying tumor-suppressive molecular mechanisms are still unclear. Here, we show that ...


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