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Immunohistochemical and molecular characterizations in urothelial carcinoma of bladder in patients less than 45 years

Weyerer, Veronika ; Schneckenpointner, Roland ; Filbeck, Thomas ; Burger, Maximilian ; Hofstaedter, Ferdinand ; Wild, Peter J. ; Fine, Samson W. ; Humphrey, Peter A. ; Dehner, Louis P. ; Amin, Mahul B. ; Rüschoff, Josef ; Boltze, Carsten ; Tannapfel, Andrea ; Zwarthoff, Ellen ; Lopez-Beltran, Antonio ; Montironi, Rodolfo ; Langner, Cord ; Stoehr, Robert ; Hartmann, Arndt ; Giedl, Johannes


Bladder tumours in early-onset patients are rare and seem to exhibit unique clinicopathological features. Only few studies have investigated somatic alterations in this specific age of onset group and evidence is accumulating of a distinct molecular behaviour of early-onset bladder tumours. We collected the largest cohort of early-onset tumours of patients 45 years old or younger and aimed to ...


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