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Synthesis and Regioselectivity in the Alkylation of 1,3,4-Oxadiazolethiones with Dihaloalkanes and Epichlorohydrin

El Ashry, El Sayed H., Boraei, Ahmed T. A. and Duerkop, Axel (2015) Synthesis and Regioselectivity in the Alkylation of 1,3,4-Oxadiazolethiones with Dihaloalkanes and Epichlorohydrin. Journal of Heterocyclic Chemistry 54 (1), pp. 95-101.

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Other URL: http://doi.org/10.1002/jhet.2545


Abstract

[GRAPHICS] The regioselectivity in the alkylation of 1,3,4-oxadiazolethiones with dihaloalkanes was found that it depends mainly on the length of the alkyl chain connecting the two halides; moreover, the formation of thiirane ring instead of epoxide ring during the alkylation with epichlorohydrin was surprising.


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Item type:Article
Date:2015
Institutions:Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik
Identification Number:
ValueType
10.1002/jhet.2545DOI
Keywords:BIOLOGICAL EVALUATION; ANTICANCER ACTIVITY; DERIVATIVES; ANTITUMOR; AGENTS; ACID;
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38505
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