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Cellular defects by deletion of ANO10 are due to deregulated local calcium signaling

Wanitchakool, Podchanart ; Ousingsawat, Jiraporn ; Sirianant, Lalida ; Cabrita, Inês ; Faria, Diana ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

TMEM16K (ANO10) belongs to a family of ion channels and phospholipid scramblases. Mutations in ANO10 cause neurological and immunological defects, and abrogated ion transport. Here we show that Ano10 knockout in epithelial cells leads to defective ion transport, attenuated volume regulation and deranged Ca2+ signaling. Intestinal epithelial cells from Ano10 null mice are reduced in size and ...

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