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Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma

Muqaku, Besnik, Eisinger, Martin, Meier, Samuel M., Tahir, Ammar , Pukrop, Tobias, Haferkamp, Sebastian, Slany, Astrid, Reichle, Albrecht and Gerner, Christopher (2016) Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma. Molecular & Cellular Proteomics 16 (1), pp. 86-99.

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Other URL: http://doi.org/10.1074/mcp.M116.063313


Abstract

Pathophysiologies of cancer-associated syndromes such as cachexia are poorly understood and no routine biomarkers have been established, yet. Using shotgun proteomics, known marker molecules including PMEL, CRP, SAA, and CSPG4 were found deregulated in patients with metastatic melanoma. Targeted analysis of 58 selected proteins with multiple reaction monitoring was applied for independent data ...

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Item type:Article
Date:2016
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1074/mcp.M116.063313DOI
Keywords:CANCER CACHEXIA; MALIGNANT-MELANOMA; MASS-SPECTROMETRY; CELLS; PROTEOME; RECEPTOR; INFLAMMATION; IDENTIFICATION; PROGRESSION; EXPRESSION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38537
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