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Ca2+ signals, cell membrane disintegration, and activation of TMEM16F during necroptosis

Ousingsawat, Jiraporn ; Cabrita, Inês ; Wanitchakool, Podchanart ; Sirianant, Lalida ; Krautwald, Stefan ; Linkermann, Andreas ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

Activated receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain like (MLKL) are essential components of the necroptotic pathway. Phosphorylated MLKL (pMLKL) is thought to induce membrane leakage, leading to cell swelling and disintegration of the cell membrane. However, the molecular identity of the necroptotic membrane pore remains unclear, and the role of pMLKL for ...

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