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Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy

Toland, Amanda Ewart ; Esslinger, Ulrike ; Garnier, Sophie ; Korniat, Agathe ; Proust, Carole ; Kararigas, Georgios ; Müller-Nurasyid, Martina ; Empana, Jean-Philippe ; Morley, Michael P. ; Perret, Claire ; Stark, Klaus ; Bick, Alexander G. ; Prasad, Sanjay K. ; Kriebel, Jennifer ; Li, Jin ; Tiret, Laurence ; Strauch, Konstantin ; O'Regan, Declan P. ; Marguiles, Kenneth B. ; Seidman, Jonathan G. ; Boutouyrie, Pierre ; Lacolley, Patrick ; Jouven, Xavier ; Hengstenberg, Christian ; Komajda, Michel ; Hakonarson, Hakon ; Isnard, Richard ; Arbustini, Eloisa ; Grallert, Harald ; Cook, Stuart A. ; Seidman, Christine E. ; Regitz-Zagrosek, Vera ; Cappola, Thomas P. ; Charron, Philippe ; Cambien, François ; Villard, Eric



Zusammenfassung

Aims Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM. Methods and results 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 6877 control subjects from 6 populations of European ancestry. ...

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