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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

Cho, Judy H. ; Baillie, J. Kenneth ; Arner, Erik ; Daub, Carsten ; De Hoon, Michiel ; Itoh, Masayoshi ; Kawaji, Hideya ; Lassmann, Timo ; Carninci, Piero ; Forrest, Alistair R. R. ; Hayashizaki, Yoshihide ; Faulkner, Geoffrey J. ; Wells, Christine A. ; Rehli, Michael ; Pavli, Paul ; Summers, Kim M. ; Hume, David A.


The FANTOM5 consortium utilised cap analysis of gene expression ( CAGE) to provide an unprecedented insight into transcriptional regulation in human cells and tissues. In the current study, we have used CAGE-based transcriptional profiling on an extended dense time course of the response of human monocyte- derived macrophages grown in macrophage colonystimulating factor (CSF1) to bacterial ...


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