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Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease

Cho, Judy H. , Baillie, J. Kenneth, Arner, Erik , Daub, Carsten, De Hoon, Michiel , Itoh, Masayoshi , Kawaji, Hideya , Lassmann, Timo, Carninci, Piero , Forrest, Alistair R. R., Hayashizaki, Yoshihide, Faulkner, Geoffrey J., Wells, Christine A. , Rehli, Michael, Pavli, Paul, Summers, Kim M. and Hume, David A. (2017) Analysis of the human monocyte-derived macrophage transcriptome and response to lipopolysaccharide provides new insights into genetic aetiology of inflammatory bowel disease. PLOS Genetics 13 (3), e1006641.

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Other URL: http://doi.org/10.1371/journal.pgen.1006641

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

The FANTOM5 consortium utilised cap analysis of gene expression ( CAGE) to provide an unprecedented insight into transcriptional regulation in human cells and tissues. In the current study, we have used CAGE-based transcriptional profiling on an extended dense time course of the response of human monocyte- derived macrophages grown in macrophage colonystimulating factor (CSF1) to bacterial ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1371/journal.pgen.1006641DOI
Keywords:NF-KAPPA-B; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; STIMULATING FACTOR-I; CROHNS-DISEASE; INTESTINAL HOMEOSTASIS; NEGATIVE REGULATOR; FUNCTIONAL VARIANTS; SUSCEPTIBILITY LOCI; MEDIATED ACTIVATION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38621
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