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Childhood adversity impacts on brain subcortical structures relevant to depression

Frodl, Thomas ; Janowitz, Deborah ; Schmaal, Lianne ; Tozzi, Leonardo ; Dobrowolny, Henrik ; Stein, Dan J. ; Veltman, Dick J. ; Wittfeld, Katharina ; van Erp, Theo G. M. ; Jahanshad, Neda ; Block, Andrea ; Hegenscheid, Katrin ; Völzke, Henry ; Lagopoulos, Jim ; Hatton, Sean N. ; Hickie, Ian B. ; Frey, Eva Maria ; Carballedo, Angela ; Brooks, Samantha J. ; Vuletic, Daniella ; Uhlmann, Anne ; Veer, Ilya M. ; Walter, Henrik ; Schnell, Knut ; Grotegerd, Dominik ; Arolt, Volker ; Kugel, Harald ; Schramm, Elisabeth ; Konrad, Carsten ; Zurowski, Bartosz ; Baune, Bernhard T. ; van der Wee, Nic J. A. ; van Tol, Marie-Jose ; Penninx, Brenda W. J. H. ; Thompson, Paul M. ; Hibar, Derrek P. ; Dannlowski, Udo ; Grabe, Hans J.



Abstract

Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical ...

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