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Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex

Holinski, Alexandra ; Heyn, Kristina ; Merkl, Rainer ; Sterner, Reinhard



Abstract

It is important to identify hotspot residues that determine protein-protein interactions in interfaces of macromolecular complexes. We have applied a combination of ancestral sequence reconstruction and protein design to identify hotspots within imidazole glycerol phosphate synthase (ImGPS). ImGPS is a key metabolic enzyme complex, which links histidine and de novo purine biosynthesis and ...

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