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Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

Hinney, A. ; Kesselmeier, M. ; Jall, S. ; Volckmar, A.-L. ; Föcker, M. ; Antel, J. ; Heid, I. M. ; Winkler, T. W. ; Grant, S. F. A. ; Guo, Y. ; Bergen, A. W. ; Kaye, W. ; Berrettini, W. ; Hakonarson, H. ; Herpertz-Dahlmann, B. ; de Zwaan, M. ; Herzog, W. ; Ehrlich, S. ; Zipfel, S. ; Egberts, K. M. ; Adan, R. ; Brandys, M. ; van Elburg, A. ; Boraska Perica, V. ; Franklin, C. S. ; Tschöp, M. H. ; Zeggini, E. ; Bulik, C. M. ; Collier, D. ; Scherag, A. ; Müller, T. D. ; Hebebrand, J.



Abstract

The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our ...

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