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Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2

Wilkes, Martin, Madej, M Gregor , Kreuter, Lydia, Rhinow, Daniel, Heinz, Veronika, De Sanctis, Silvia, Ruppel, Sabine, Richter, Rebecca M, Joos, Friederike, Grieben, Marina, Pike, Ashley C W, Huiskonen, Juha T , Carpenter, Elisabeth P, Kühlbrandt, Werner , Witzgall, Ralph and Ziegler, Christine (2017) Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2. Nature Structural & Molecular Biology 24 (2), pp. 123-130.

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Other URL: http://doi.org/10.1038/nsmb.3357


Abstract

Polycystin-2 (PC2), a calcium-activated cation TRP channel, is involved in diverse Ca2+ signaling pathways. Malfunctioning Ca2+ regulation in PC2 causes autosomal-dominant polycystic kidney disease. Here we report two cryo-EM structures of distinct channel states of full-length human PC2 in complex with lipids and cations. The structures reveal conformational differences in the selectivity filter ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Christine Ziegler
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Ralph Witzgall
Identification Number:
ValueType
10.1038/nsmb.3357DOI
Keywords:EM STRUCTURE DETERMINATION; HIGH-LEVEL EXPRESSION; BEAM-INDUCED MOTION; KIDNEY-DISEASE; CRYO-EM; ELECTRON CRYOMICROSCOPY; CATION CHANNEL; N-GLYCOSYLATION; PKD2; MECHANISMS;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38754
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