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NHE1 expression at wound margins increases time-dependently during physiological healing

Haverkampf, Sonja ; Heider, Judith ; Weiß, Katharina T. ; Haubner, Frank ; Ettl, Tobias ; Schreml, Julia ; Hedtrich, Sarah ; von Süßkind-Schwendi, Marietta ; Berneburg, Mark ; Karrer, Sigrid ; Dissemond, Joachim ; Schreml, Stephan



Abstract

Wound repair is an orchestrated process, encompassing the phases of inflammation, proliferation and tissue remodeling. In this context, sodium hydrogen exchanger 1 (NHE1) is crucial to epidermal barrier integrity and acidification. Recently, we found that extracellular pH (pHe) on wound surfaces is dramatically increased initially after barrier disruption, and that pHe decreases gradually during ...

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