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Development of an UHPLC-UV-Method for Quantification of Direct Oral Anticoagulants

Boehr, Sebastian ; Haen, Ekkehard


Background: Direct oral anticoagulants currently have no indication for monitoring even though there are data that imply that individual dosing can improve and add safety to the therapy. Methods: An ultra-high performance liquid chromatography method with ultra violet detection has been developed and validated for apixaban, dabigatran, dabigatran etexilate, and rivaroxaban. Protein precipitation ...


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