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Development of an UHPLC-UV-Method for Quantification of Direct Oral Anticoagulants

Boehr, Sebastian and Haen, Ekkehard (2017) Development of an UHPLC-UV-Method for Quantification of Direct Oral Anticoagulants. Therapeutic Drug Monitoring 39 (1), pp. 66-76.

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Other URL: http://doi.org/10.1097/FTD.0000000000000355


Abstract

Background: Direct oral anticoagulants currently have no indication for monitoring even though there are data that imply that individual dosing can improve and add safety to the therapy. Methods: An ultra-high performance liquid chromatography method with ultra violet detection has been developed and validated for apixaban, dabigatran, dabigatran etexilate, and rivaroxaban. Protein precipitation ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1097/FTD.0000000000000355DOI
Keywords:DIRECT THROMBIN INHIBITOR; FACTOR XA INHIBITOR; ATRIAL-FIBRILLATION; LIQUID-CHROMATOGRAPHY; COAGULATION ASSAYS; MASS-SPECTROMETRY; PHARMACOKINETICS; WARFARIN; PHARMACODYNAMICS; THERAPY; dose-related range; assumed therapeutically effective concentrations; direct oral anticoagulants; apixaban; rivaroxaban; dabigatran; ultra-high performance liquid chromatography
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38768
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