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Type-7 metabotropic glutamate receptors negatively regulate α 1 -adrenergic receptor signalling

Iacovelli, Luisa, Di Menna, Luisa, Peterlik, Daniel, Stangl, Christina, Orlando, Rosamaria, Molinaro, Gemma, De Blasi, Antonio, Bruno, Valeria, Battaglia, Giuseppe , Flor, Peter J., Uschold-Schmidt, Nicole and Nicoletti, Ferdinando (2017) Type-7 metabotropic glutamate receptors negatively regulate α 1 -adrenergic receptor signalling. Neuropharmacology 113, pp. 343-353.

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Other URL: http://doi.org/10.1016/j.neuropharm.2016.10.018


Abstract

We studied the interaction between mGlu7 and alpha(1)-adrenergic receptors in heterologous expression systems, brain slices, and living animals. L-2-Amino-4-phosphonobutanoate (L-AP4), and L-serine-O-phosphate (L-SOP), which activate group III mGlu receptors, restrained the stimulation of polyphosphoinositide (PI) hydrolysis induced by the alpha(1)-adrenergic receptor agonist, phenylephrine, in ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor)
Identification Number:
ValueType
10.1016/j.neuropharm.2016.10.018DOI
Keywords:CEREBROCORTICAL NERVE-TERMINALS; LONG-TERM DEPRESSION; MEDIAL PREFRONTAL CORTEX; MGLU7 RECEPTOR; BETA-ARRESTIN; SYNAPTIC PLASTICITY; MICE LACKING; RAT-BRAIN; PSYCHIATRIC-DISORDERS; ADRENERGIC-RECEPTORS; mGlu7 receptors; alpha(1)-adrenergic receptor; Stress; Cross-talk; G proteins
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38790
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