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Type-7 metabotropic glutamate receptors negatively regulate α 1 -adrenergic receptor signalling

Iacovelli, Luisa ; Di Menna, Luisa ; Peterlik, Daniel ; Stangl, Christina ; Orlando, Rosamaria ; Molinaro, Gemma ; De Blasi, Antonio ; Bruno, Valeria ; Battaglia, Giuseppe ; Flor, Peter J. ; Uschold-Schmidt, Nicole ; Nicoletti, Ferdinando


We studied the interaction between mGlu7 and alpha(1)-adrenergic receptors in heterologous expression systems, brain slices, and living animals. L-2-Amino-4-phosphonobutanoate (L-AP4), and L-serine-O-phosphate (L-SOP), which activate group III mGlu receptors, restrained the stimulation of polyphosphoinositide (PI) hydrolysis induced by the alpha(1)-adrenergic receptor agonist, phenylephrine, in ...


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