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Defibrotide for children and adults with hepatic veno-occlusive disease post hematopoietic cell transplantation

Corbacioglu, Selim and Richardson, Paul G. (2017) Defibrotide for children and adults with hepatic veno-occlusive disease post hematopoietic cell transplantation. Expert Review of Gastroenterology & Hepatology 11 (10), pp. 885-898.

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Other URL: http://doi.org/10.1080/17474124.2017.1370372


Introduction: Hepatic veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a complication that is typically associated with conditioning for hematopoietic stem cell transplantation (HSCT). In patients with concomitant multi-organ dysfunction, mortality may be >80%. Recently, the European Society for Blood and Marrow Transplantation established separate criteria for diagnosis and ...


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Item type:Article
Institutions:Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation
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Keywords:BONE-MARROW-TRANSPLANTATION; SYNDROME/VENO-OCCLUSIVE DISEASE; HIGH-RISK POPULATION; ENDOTHELIAL-CELLS; OBSTRUCTION SYNDROME; COMPASSIONATE-USE; URSODEOXYCHOLIC ACID; SIGNIFICANT TOXICITY; MULTIORGAN FAILURE; EUROPEAN-SOCIETY; Defibrotide; endothelial cell activation; fibrinolysis; hematopoietic stem cell transplantation; hepatic veno-occlusive disease; multi-organ dysfunction; multi-organ failure; sinusoidal obstruction syndrome; thrombosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38834
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