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Potential Role of the PD-1/PD-L1 Axis in the Immune Regulation of Chronic GVHD

Klobuch, Sebastian, Weber, Daniela, Holler, Barbara, Herr, Wolfgang, Holler, Ernst and Wolff, Daniel (2017) Potential Role of the PD-1/PD-L1 Axis in the Immune Regulation of Chronic GVHD. Oncology Research and Treatment 40 (7-8), pp. 447-450.

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Other URL: http://doi.org/10.1159/000471768


Abstract

Background: Antibodies blocking the PD-1/PD-L1 axis have been shown to have substantial antitumor effects also in the treatment of Hodgkin's lymphoma (HL) relapsing after conventional chemotherapy or even autologous hematopoietic stem cell transplantation (autoHSCT). In the case of allogeneic HSCT (alloHSCT), this treatment bears the risk of inducing graft-versus-host disease (GVHD). So far, only ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1159/000471768DOI
Keywords:VERSUS-HOST-DISEASE; REFRACTORY HODGKINS LYMPHOMA; STEM-CELL TRANSPLANTATION; T-CELLS; NIVOLUMAB; PATHWAY; EXPRESSION; LETHALITY; BLOCKADE; PATIENT; Hodgkin's lymphoma; Immunotherapy; Stem cell transplantation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38860
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