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Potential Role of the PD-1/PD-L1 Axis in the Immune Regulation of Chronic GVHD

Klobuch, Sebastian ; Weber, Daniela ; Holler, Barbara ; Herr, Wolfgang ; Holler, Ernst ; Wolff, Daniel



Abstract

Background: Antibodies blocking the PD-1/PD-L1 axis have been shown to have substantial antitumor effects also in the treatment of Hodgkin's lymphoma (HL) relapsing after conventional chemotherapy or even autologous hematopoietic stem cell transplantation (autoHSCT). In the case of allogeneic HSCT (alloHSCT), this treatment bears the risk of inducing graft-versus-host disease (GVHD). So far, only ...

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