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Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

Dogliotti, Giada, Kullmann, Lars, Dhumale, Pratibha, Thiele, Christian, Panichkina, Olga, Mendl, Gudrun, Houben, Roland, Haferkamp, Sebastian, Püschel, Andreas W. and Krahn, Michael P. (2017) Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression. Nature Communications 8, p. 15747.

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Other URL: http://doi.org/10.1038/ncomms15747

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

The serine/threonine kinase LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Many downstream pathways controlled by LKB1 have been described but little is known about the upstream regulatory mechanisms. Here we show that targeting of the kinase to the membrane by a direct binding of LKB1 ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Dermatologie und Venerologie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Identification Number:
ValueType
10.1038/ncomms15747DOI
Keywords:PEUTZ-JEGHERS-SYNDROME; DEPENDENT PROTEIN-KINASE; HUMAN CANCER-CELLS; PHOSPHOLIPASE-D; MAMMALIAN TARGET; NEURONAL POLARITY; SIGNALING PATHWAY; DROSOPHILA LKB1; RAPAMYCIN MTOR; SYNDROME GENE;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38874
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