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Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression

Dogliotti, Giada ; Kullmann, Lars ; Dhumale, Pratibha ; Thiele, Christian ; Panichkina, Olga ; Mendl, Gudrun ; Houben, Roland ; Haferkamp, Sebastian ; Püschel, Andreas W. ; Krahn, Michael P.



Abstract

The serine/threonine kinase LKB1 regulates various cellular processes such as cell proliferation, energy homeostasis and cell polarity and is frequently downregulated in various tumours. Many downstream pathways controlled by LKB1 have been described but little is known about the upstream regulatory mechanisms. Here we show that targeting of the kinase to the membrane by a direct binding of LKB1 ...

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