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A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping

Schütz, Stefan, Nöldeke, Erik R. and Sprangers, Remco (2017) A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping. Nucleic Acids Research 45 (11), pp. 6911-6922.

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Other URL: http://doi.org/10.1093/nar/gkx353

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Abstract

Cellular liquid-liquid phase separation (LLPS) results in the formation of dynamic granules that play an important role in many biological processes. On a molecular level, the clustering of proteins into a confined space results from an indefinite network of intermolecular interactions. Here, we introduce and exploit a novel high-throughput bottom-up approach to study how the interactions between ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Identification Number:
ValueType
10.1093/nar/gkx353DOI
Keywords:INTRINSICALLY DISORDERED PROTEINS; C-TERMINAL DOMAIN; PHASE-SEPARATION; SACCHAROMYCES-CEREVISIAE; STRESS GRANULES; LIQUID DROPLETS; TRANSITIONS; DEGRADATION; CELLS; EDC3;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38882
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