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A synergistic network of interactions promotes the formation of in vitro processing bodies and protects mRNA against decapping

Schütz, Stefan ; Nöldeke, Erik R. ; Sprangers, Remco



Abstract

Cellular liquid-liquid phase separation (LLPS) results in the formation of dynamic granules that play an important role in many biological processes. On a molecular level, the clustering of proteins into a confined space results from an indefinite network of intermolecular interactions. Here, we introduce and exploit a novel high-throughput bottom-up approach to study how the interactions between ...

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