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Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner

Slattery, David A., Neumann, Inga D., Flor, Peter J. and Zoicas, Iulia (2017) Pharmacological modulation of metabotropic glutamate receptor subtype 5 and 7 impairs extinction of social fear in a time-point-dependent manner. Behavioural Brain Research 328, pp. 57-61.

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Other URL: http://doi.org/10.1016/j.bbr.2017.04.010


Abstract

Pharmacological modulation of metabotropic glutamate receptor subtype 5 (mGluR5) and 7 (mGluR7) was shown to attenuate the acquisition and to facilitate the extinction of cued and contextual, non-social, fear. Using the allosteric mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) and the allosteric mGluR7 agonist N,N'-dibenzyhydryl-ethane-1,2-diamine dihydrochloride (AMN082), we aimed ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Molecular and Cellular Neurobiology (Prof. Dr. Peter J. Flor)
Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Identification Number:
ValueType
10.1016/j.bbr.2017.04.010DOI
Keywords:POSITIVE ALLOSTERIC MODULATION; POSTTRAUMATIC-STRESS-DISORDER; D-CYCLOSERINE; CONTROLLED-TRIAL; FACILITATES EXTINCTION; EXPOSURE THERAPY; ANXIETY DISORDER; CONDITIONED FEAR; REDUCES FEAR; MALE-MICE; Social fear conditioning extinction; MPEP; AMN082; mGluR5; mGluR7
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38885
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