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Pwp2 mediates UTP-B assembly via two structurally independent domains

Boissier, Fanny ; Schmidt, Christina Maria ; Linnemann, Jan ; Fribourg, Sébastien ; Perez-Fernandez, Jorge



Abstract

The SSU processome constitutes a large ribonucleoprotein complex involved in the early steps of ribosome biogenesis. UTP-B is one of the first multi-subunit protein complexes that associates with the pre-ribosomal RNA to form the SSU processome. To understand the molecular basis of the hierarchical assembly of the SSU-processome, we have undergone a structural and functional analysis of the UTP-B ...

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