Go to content
UR Home

Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Akey, Joshua M. ; Shungin, Dmitry ; Deng, Wei Q. ; Varga, Tibor V. ; Luan, Jian'an ; Mihailov, Evelin ; Metspalu, Andres ; Morris, Andrew P. ; Forouhi, Nita G. ; Lindgren, Cecilia ; Magnusson, Patrik K. E. ; Pedersen, Nancy L. ; Hallmans, Göran ; Chu, Audrey Y. ; Justice, Anne E. ; Graff, Mariaelisa ; Winkler, Thomas W. ; Rose, Lynda M. ; Langenberg, Claudia ; Cupples, L. Adrienne ; Ridker, Paul M. ; Wareham, Nicholas J. ; Ong, Ken K. ; Loos, Ruth J. F. ; Chasman, Daniel I. ; Ingelsson, Erik ; Kilpeläinen, Tuomas O. ; Scott, Robert A. ; Mägi, Reedik ; Pare, Guillaume ; Franks, Paul W.



Abstract

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (GxE) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (P-v), GxE interaction effects (with smoking and physical activity), and marginal genetic ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons