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Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions

Akey, Joshua M., Shungin, Dmitry, Deng, Wei Q. , Varga, Tibor V., Luan, Jian'an, Mihailov, Evelin, Metspalu, Andres, Morris, Andrew P., Forouhi, Nita G. , Lindgren, Cecilia , Magnusson, Patrik K. E., Pedersen, Nancy L., Hallmans, Göran, Chu, Audrey Y., Justice, Anne E., Graff, Mariaelisa, Winkler, Thomas W., Rose, Lynda M., Langenberg, Claudia, Cupples, L. Adrienne, Ridker, Paul M., Wareham, Nicholas J., Ong, Ken K. , Loos, Ruth J. F., Chasman, Daniel I., Ingelsson, Erik , Kilpeläinen, Tuomas O., Scott, Robert A., Mägi, Reedik , Paré, Guillaume and Franks, Paul W. (2017) Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLOS Genetics 13 (6), e1006812.

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Other URL: http://doi.org/10.1371/journal.pgen.1006812

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Abstract

Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (GxE) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and BMI in up to 44,211 participants and investigated relationships between variance effects (P-v), GxE interaction effects (with smoking and physical activity), and marginal genetic ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Identification Number:
ValueType
10.1371/journal.pgen.1006812DOI
Keywords:BODY-MASS INDEX; GENOME-WIDE METAANALYSIS; PHENOTYPIC VARIABILITY; VARIANTS; OBESITY; INSIGHTS; SNPS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38920
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