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A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Tay, Tuan Leng ; Mai, Dominic ; Dautzenberg, Jana ; Fernández-Klett, Francisco ; Lin, Gen ; Sagar, ; Datta, Moumita ; Drougard, Anne ; Stempfl, Thomas ; Ardura-Fabregat, Alberto ; Staszewski, Ori ; Margineanu, Anca ; Sporbert, Anje ; Steinmetz, Lars M ; Pospisilik, J Andrew ; Jung, Steffen ; Priller, Josef ; Grün, Dominic ; Ronneberger, Olaf ; Prinz, Marco


Microglia constitute a highly specialized network of tissue-resident immune cells that is important for the control of tissue homeostasis and the resolution of diseases of the CNS. Little is known about how their spatial distribution is established and maintained in vivo. Here we establish a new multicolor fluorescence fate mapping system to monitor microglial dynamics during steady state and ...


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