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A new fate mapping system reveals context-dependent random or clonal expansion of microglia

Tay, Tuan Leng , Mai, Dominic, Dautzenberg, Jana, Fernández-Klett, Francisco, Lin, Gen, Sagar, , Datta, Moumita, Drougard, Anne, Stempfl, Thomas, Ardura-Fabregat, Alberto, Staszewski, Ori, Margineanu, Anca , Sporbert, Anje, Steinmetz, Lars M, Pospisilik, J Andrew, Jung, Steffen , Priller, Josef, Grün, Dominic, Ronneberger, Olaf and Prinz, Marco (2017) A new fate mapping system reveals context-dependent random or clonal expansion of microglia. Nature Neuroscience 20 (6), pp. 793-803.

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Other URL: http://doi.org/10.1038/nn.4547


Abstract

Microglia constitute a highly specialized network of tissue-resident immune cells that is important for the control of tissue homeostasis and the resolution of diseases of the CNS. Little is known about how their spatial distribution is established and maintained in vivo. Here we establish a new multicolor fluorescence fate mapping system to monitor microglial dynamics during steady state and ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie
Identification Number:
ValueType
10.1038/nn.4547DOI
Keywords:HEMATOPOIETIC STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; ADULT-MOUSE BRAIN; IN-VIVO; RESIDENT MICROGLIA; YOLK-SAC; MACROPHAGES; INFLAMMATION; MONOCYTES; PROLIFERATION;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38959
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