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Cortical abnormalities in adults and adolescents with major depression based on brain scans from 20 cohorts worldwide in the ENIGMA Major Depressive Disorder Working Group

Schmaal, L ; Hibar, D P ; Sämann, P G ; Hall, G B ; Baune, B T ; Jahanshad, N ; Cheung, J W ; van Erp, T G M ; Bos, D ; Ikram, M A ; Vernooij, M W ; Niessen, W J ; Tiemeier, H ; Hofman, A ; Wittfeld, K ; Grabe, H J ; Janowitz, D ; Bülow, R ; Selonke, M ; Völzke, H ; Grotegerd, D ; Dannlowski, U ; Arolt, V ; Opel, N ; Heindel, W ; Kugel, H ; Hoehn, D ; Czisch, M ; Couvy-Duchesne, B ; Rentería, M E ; Strike, L T ; Wright, M J ; Mills, N T ; de Zubicaray, G I ; McMahon, K L ; Medland, S E ; Martin, N G ; Gillespie, N A ; Goya-Maldonado, R ; Gruber, O ; Krämer, B ; Hatton, S N ; Lagopoulos, J ; Hickie, I B ; Frodl, T ; Carballedo, A ; Frey, E M ; van Velzen, L S ; Penninx, B W J H ; van Tol, M-J ; van der Wee, N J ; Davey, C G ; Harrison, B J ; Mwangi, B ; Cao, B ; Soares, J C ; Veer, I M ; Walter, H ; Schoepf, D ; Zurowski, B ; Konrad, C ; Schramm, E ; Normann, C ; Schnell, K ; Sacchet, M D ; Gotlib, I H ; MacQueen, G M ; Godlewska, B R ; Nickson, T ; McIntosh, A M ; Papmeyer, M ; Whalley, H C ; Hall, J ; Sussmann, J E ; Li, M ; Walter, M ; Aftanas, L ; Brack, I ; Bokhan, N A ; Thompson, P M ; Veltman, D J



Abstract

The neuro-anatomical substrates of major depressive disorder (MDD) are still not well understood, despite many neuroimaging studies over the past few decades. Here we present the largest ever worldwide study by the ENIGMA (Enhancing Neuro Imaging Genetics through Meta-Analysis) Major Depressive Disorder Working Group on cortical structural alterations in MDD. Structural T1-weighted brain magnetic ...

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