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Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation

Peled, Jonathan U. ; Devlin, Sean M. ; Staffas, Anna ; Lumish, Melissa ; Khanin, Raya ; Littmann, Eric R. ; Ling, Lilan ; Kosuri, Satyajit ; Maloy, Molly ; Slingerland, John B. ; Ahr, Katya F. ; Porosnicu Rodriguez, Kori A. ; Shono, Yusuke ; Slingerland, Ann E. ; Docampo, Melissa D. ; Sung, Anthony D. ; Weber, Daniela ; Alousi, Amin M. ; Gyurkocza, Boglarka ; Ponce, Doris M. ; Barker, Juliet N. ; Perales, Miguel-Angel ; Giralt, Sergio A. ; Taur, Ying ; Pamer, Eric G. ; Jenq, Robert R. ; van den Brink, Marcel R.M.



Abstract

PurposeThe major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, ...

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