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Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation

Peled, Jonathan U. , Devlin, Sean M., Staffas, Anna, Lumish, Melissa, Khanin, Raya, Littmann, Eric R., Ling, Lilan, Kosuri, Satyajit, Maloy, Molly, Slingerland, John B., Ahr, Katya F., Porosnicu Rodriguez, Kori A., Shono, Yusuke, Slingerland, Ann E., Docampo, Melissa D., Sung, Anthony D., Weber, Daniela, Alousi, Amin M., Gyurkocza, Boglarka, Ponce, Doris M., Barker, Juliet N., Perales, Miguel-Angel, Giralt, Sergio A., Taur, Ying, Pamer, Eric G., Jenq, Robert R. and van den Brink, Marcel R.M. (2017) Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. Journal of Clinical Oncology 35 (15), pp. 1650-1659.

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Other URL: http://doi.org/10.1200/JCO.2016.70.3348


Abstract

PurposeThe major causes of mortality after allogeneic hematopoietic-cell transplantation (allo-HCT) are relapse, graft-versus-host disease (GVHD), and infection. We have reported previously that alterations in the intestinal flora are associated with GVHD, bacteremia, and reduced overall survival after allo-HCT. Because intestinal bacteria are potent modulators of systemic immune responses, ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1200/JCO.2016.70.3348DOI
Keywords:VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; UNRELATED DONORS; GUT MICROBIOTA; CORD-BLOOD; LEUKEMIA; CYCLOPHOSPHAMIDE; INFLAMMATION; DIVERSITY; MORTALITY;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:38991
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