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Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms

Adkins, Amy E., Hack, Laura M., Bigdeli, Tim B., Williamson, Vernell S., McMichael, G. Omari, Mamdani, Mohammed, Edwards, Alexis C., Aliev, Fazil , Chan, Robin F. , Bhandari, Poonam, Raabe, Richard C., Alaimo, Joseph T., Blackwell, GinaMari G., Moscati, Arden, Poland, Ryan S., Rood, Benjamin, Patterson, Diana G., Walsh, Dermot, Whitfield, John B., Zhu, Gu, Montgomery, Grant W. , Henders, Anjali K., Martin, Nicholas G., Heath, Andrew C., Madden, Pamela A.F., Frank, Josef, Ridinger, Monika, Wodarz, Norbert, Soyka, Michael, Zill, Peter, Ising, Marcus, Nöthen, Markus M., Kiefer, Falk, Rietschel, Marcella, Gelernter, Joel , Sherva, Richard, Koesterer, Ryan, Almasy, Laura, Zhao, Hongyu, Kranzler, Henry R., Farrer, Lindsay A. , Maher, Brion S., Prescott, Carol A., Dick, Danielle M., Bacanu, Silviu A., Mathies, Laura D., Davies, Andrew G., Vladimirov, Vladimir I., Grotewiel, Mike, Bowers, M. Scott, Bettinger, Jill C., Webb, Bradley T. , Miles, Michael F., Kendler, Kenneth S. and Riley, Brien P. (2017) Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Alcoholism: Clinical and Experimental Research 41 (5), pp. 911-928.

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Other URL: http://doi.org/10.1111/acer.13362


Abstract

BackgroundAlcohol dependence (AD) shows evidence for genetic liability, but genes influencing risk remain largely unidentified. MethodsWe conducted a genomewide association study in 706 related AD cases and 1,748 unscreened population controls from Ireland. We sought replication in 15,496 samples of European descent. We used model organisms (MOs) to assess the role of orthologous genes in ethanol ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Psychiatrie und Psychotherapie
Identification Number:
ValueType
10.1111/acer.13362DOI
Keywords:RYANODINE RECEPTOR EXPRESSION; NATIONAL EPIDEMIOLOGIC SURVEY; TISSUE-PLASMINOGEN ACTIVATOR; DOPAMINE D-1 RECEPTORS; WIDE ASSOCIATION; CAENORHABDITIS-ELEGANS; PLACE PREFERENCE; NONCODING RNA; C. ELEGANS; WITHDRAWAL; Alcohol Dependence; COL6A3; KLF12; LOC339975; RYR3
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39052
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