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Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Noack, Katrin ; Mahendrarajah, Nisintha ; Hennig, Dorle ; Schmidt, Luisa ; Grebien, Florian ; Hildebrand, Dagmar ; Christmann, Markus ; Kaina, Bernd ; Sellmer, Andreas ; Mahboobi, Siavosh ; Kubatzky, Katharina ; Heinzel, Thorsten ; Krämer, Oliver H.



Abstract

The treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) induces granulocytic differentiation. This process renders APL cells resistant to cytotoxic chemotherapies. Epigenetic regulators of the histone deacetylases (HDACs) family, which comprise four classes (I-IV), critically control the development and progression of APL. We set out to clarify the parameters that ...

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