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Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells

Noack, Katrin, Mahendrarajah, Nisintha, Hennig, Dorle, Schmidt, Luisa, Grebien, Florian , Hildebrand, Dagmar, Christmann, Markus, Kaina, Bernd, Sellmer, Andreas, Mahboobi, Siavosh, Kubatzky, Katharina, Heinzel, Thorsten and Krämer, Oliver H. (2017) Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells. Archives of Toxicology 91 (5), pp. 2191-2208.

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Other URL: http://doi.org/10.1007/s00204-016-1878-5


Abstract

The treatment of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA) induces granulocytic differentiation. This process renders APL cells resistant to cytotoxic chemotherapies. Epigenetic regulators of the histone deacetylases (HDACs) family, which comprise four classes (I-IV), critically control the development and progression of APL. We set out to clarify the parameters that ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Identification Number:
ValueType
10.1007/s00204-016-1878-5DOI
Keywords:ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NF-KAPPA-B; CCAAT/ENHANCER-BINDING-PROTEINS; DNA-DAMAGE RESPONSE; PML-RAR-ALPHA; CLASS-I HDAC; VALPROIC ACID; MULTIPLE-MYELOMA; C/EBP-BETA; APL; ATRA; DNA damage; HDAC; HDACi; Histone acetylation
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39054
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