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High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

Kitada, Kento, Daub, Steffen, Zhang, Yahua, Klein, Janet D., Nakano, Daisuke, Pedchenko, Tetyana, Lantier, Louise, LaRocque, Lauren M., Marton, Adriana, Neubert, Patrick, Schröder, Agnes, Rakova, Natalia, Jantsch, Jonathan, Dikalova, Anna E., Dikalov, Sergey I., Harrison, David G., Müller, Dominik N., Nishiyama, Akira, Rauh, Manfred, Harris, Raymond C., Luft, Friedrich C., Wasserman, David H., Sands, Jeff M. and Titze, Jens (2017) High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation. Journal of Clinical Investigation 127 (5), pp. 1944-1959.

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Other URL: http://doi.org/10.1172/JCI88532


Abstract

Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and reduced renal nerve activity, actions that concomitantly increase urinary Na+ excretion and lead to increased urine volume. The resulting natriuresis-driven diuretic water loss is assumed to control the extracellular volume. Here, we have ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1172/JCI88532DOI
Keywords:ACTIVATED PROTEIN-KINASE; ACETYL-COA CARBOXYLASE; AMINO-ACID-METABOLISM; AFRICAN LUNGFISH; UREA TRANSPORTER; IN-VIVO; PROTOPTERUS-AETHIOPICUS; PROLONGED STARVATION; RAT MUSCLE; ESTIVATION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39058
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