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High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation

Kitada, Kento ; Daub, Steffen ; Zhang, Yahua ; Klein, Janet D. ; Nakano, Daisuke ; Pedchenko, Tetyana ; Lantier, Louise ; LaRocque, Lauren M. ; Marton, Adriana ; Neubert, Patrick ; Schröder, Agnes ; Rakova, Natalia ; Jantsch, Jonathan ; Dikalova, Anna E. ; Dikalov, Sergey I. ; Harrison, David G. ; Müller, Dominik N. ; Nishiyama, Akira ; Rauh, Manfred ; Harris, Raymond C. ; Luft, Friedrich C. ; Wasserman, David H. ; Sands, Jeff M. ; Titze, Jens



Abstract

Natriuretic regulation of extracellular fluid volume homeostasis includes suppression of the renin-angiotensin-aldosterone system, pressure natriuresis, and reduced renal nerve activity, actions that concomitantly increase urinary Na+ excretion and lead to increased urine volume. The resulting natriuresis-driven diuretic water loss is assumed to control the extracellular volume. Here, we have ...

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