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HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates

García-Arriaza, Juan, Perdiguero, Beatriz , Heeney, Jonathan L., Seaman, Michael S., Montefiori, David C., Yates, Nicole L., Tomaras, Georgia D., Ferrari, Guido , Foulds, Kathryn E., Roederer, Mario, Self, Steven G., Borate, Bhavesh, Gottardo, Raphael, Phogat, Sanjay, Tartaglia, Jim, Barnett, Susan W., Burke, Brian, Cristillo, Anthony D., Weiss, Deborah E., Lee, Carter, Kibler, Karen V., Jacobs, Bertram L., Wagner, Ralf, Ding, Song, Pantaleo, Giuseppe, Esteban, Mariano and Silvestri, Guido (2017) HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates. Journal of Virology 91 (9).

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Other URL: http://doi.org/10.1128/JVI.02182-16


Abstract

The nonreplicating attenuated poxvirus vector NYVAC expressing clade C(CN54) HIV-1 Env(gp120) and Gag-Pol-Nef antigens (NYVAC-C) showed limited immunogenicity in phase I clinical trials. To enhance the capacity of the NYVAC vector to trigger broad humoral responses and a more balanced activation of CD4(+) and CD8(+) T cells, here we compared the HIV-1-specific immunogenicity elicited in nonhuman ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1128/JVI.02182-16DOI
Keywords:NEUTRALIZING ANTIBODY-ASSAY; CLADE-C; DNA PRIME; RHESUS MACAQUES; PROTECTIVE EFFICACY; HIV VACCINES; RESPONSES; IMMUNOGENICITY; BOOST; TRIAL; HIV-1; poxvirus; NYVAC; B19R; nonhuman primates; immunogenicity; cellular responses; humoral responses
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39063
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