Go to content
UR Home

HIV/AIDS Vaccine Candidates Based on Replication-Competent Recombinant Poxvirus NYVAC-C-KC Expressing Trimeric gp140 and Gag-Derived Virus-Like Particles or Lacking the Viral Molecule B19 That Inhibits Type I Interferon Activate Relevant HIV-1-Specific B and T Cell Immune Functions in Nonhuman Primates

García-Arriaza, Juan ; Perdiguero, Beatriz ; Heeney, Jonathan L. ; Seaman, Michael S. ; Montefiori, David C. ; Yates, Nicole L. ; Tomaras, Georgia D. ; Ferrari, Guido ; Foulds, Kathryn E. ; Roederer, Mario ; Self, Steven G. ; Borate, Bhavesh ; Gottardo, Raphael ; Phogat, Sanjay ; Tartaglia, Jim ; Barnett, Susan W. ; Burke, Brian ; Cristillo, Anthony D. ; Weiss, Deborah E. ; Lee, Carter ; Kibler, Karen V. ; Jacobs, Bertram L. ; Wagner, Ralf ; Ding, Song ; Pantaleo, Giuseppe ; Esteban, Mariano ; Silvestri, Guido


The nonreplicating attenuated poxvirus vector NYVAC expressing clade C(CN54) HIV-1 Env(gp120) and Gag-Pol-Nef antigens (NYVAC-C) showed limited immunogenicity in phase I clinical trials. To enhance the capacity of the NYVAC vector to trigger broad humoral responses and a more balanced activation of CD4(+) and CD8(+) T cells, here we compared the HIV-1-specific immunogenicity elicited in nonhuman ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: daten@ur.de
0941 943 -5707

Contact persons