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BMP-9 interferes with liver regeneration and promotes liver fibrosis

Breitkopf-Heinlein, Katja ; Meyer, Christoph ; König, Courtney ; Gaitantzi, Haristi ; Addante, Annalisa ; Thomas, Maria ; Wiercinska, Eliza ; Cai, Chen ; Li, Qi ; Wan, Fengqi ; Hellerbrand, Claus ; Valous, Nektarios A. ; Hahnel, Maximilian ; Ehlting, Christian ; Bode, Johannes G. ; Müller-Bohl, Stephanie ; Klingmüller, Ursula ; Altenöder, Jutta ; Ilkavets, Iryna ; Goumans, Marie-José ; Hawinkels, Lukas J. A. C. ; Lee, Se-Jin ; Wieland, Matthias ; Mogler, Carolin ; Ebert, Matthias P. ; Herrera, Blanca ; Augustin, Hellmut ; Sánchez, Aránzazu ; Dooley, Steven ; ten Dijke, Peter



Abstract

Objective Bone morphogenetic protein (BMP)-9, a member of the transforming growth factor-beta family of cytokines, is constitutively produced in the liver. Systemic levels act on many organs and tissues including bone and endothelium, but little is known about its hepatic functions in health and disease. Design Levels of BMP-9 and its receptors were analysed in primary liver cells. Direct effects ...

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