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Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

Hu, Cheng, Eriksson, Joel , Haring, Robin , Grarup, Niels, Vandenput, Liesbeth, Wallaschofski, Henri, Lorentzen, Erik , Hansen, Torben, Mellström, Dan , Pedersen, Oluf, Nauck, Matthias, Lorentzon, Mattias, Nystrup Husemoen, Lise Lotte, Völzke, Henry, Karlsson, Magnus, Baumeister, Sebastian E. , Linneberg, Allan and Ohlsson, Claes (2017) Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis. PLOS ONE 12 (4), e0176277.

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Other URL: http://doi.org/10.1371/journal.pone.0176277

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Abstract

Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting Five cohorts from Denmark, Germany and Sweden ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin
Identification Number:
ValueType
10.1371/journal.pone.0176277DOI
Keywords:HORMONE-BINDING GLOBULIN; BODY-MASS INDEX; GENOME-WIDE ASSOCIATION; ELDERLY-MEN; OLDER MEN; FTO GENE; HYPOGONADOTROPIC HYPOGONADISM; METABOLIC SYNDROME; MUSCLE STRENGTH; RISK-FACTORS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39077
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