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Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

Hu, Cheng ; Eriksson, Joel ; Haring, Robin ; Grarup, Niels ; Vandenput, Liesbeth ; Wallaschofski, Henri ; Lorentzen, Erik ; Hansen, Torben ; Mellström, Dan ; Pedersen, Oluf ; Nauck, Matthias ; Lorentzon, Mattias ; Nystrup Husemoen, Lise Lotte ; Völzke, Henry ; Karlsson, Magnus ; Baumeister, Sebastian E. ; Linneberg, Allan ; Ohlsson, Claes



Abstract

Context Obesity in men is associated with low serum testosterone and both are associated with several diseases and increased mortality. Objectives Examine the direction and causality of the relationship between body mass index (BMI) and serum testosterone. Design Bi-directional Mendelian randomization (MR) analysis on prospective cohorts. Setting Five cohorts from Denmark, Germany and Sweden ...

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