Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | European Journal of Heart Failure | ||||
Verlag: | Wiley | ||||
Ort der Veröffentlichung: | HOBOKEN | ||||
Band: | 19 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 4 | ||||
Seitenbereich: | S. 579-587 | ||||
Datum: | 2017 | ||||
Institutionen: | Medizin > Lehrstuhl für Innere Medizin II | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | POSITIVE AIRWAY PRESSURE; CHEYNE-STOKES RESPIRATION; RANDOMIZED CONTROLLED-TRIAL; BLOOD-PRESSURE; PREVALENCE; PREDICTORS; MORTALITY; OUTCOMES; HYPERTENSION; DYSFUNCTION; Heart failure; Sleep-disordered breathing; Obstructive sleep apnoea; Central sleep apnoea; Adaptive servo-ventilation; Mortality; Cardiovascular hospital admissions | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 39108 |
Zusammenfassung
Introduction Both types of sleep-disordered breathing (SDB), obstructive and central sleep apnoea (OSA and CSA, respectively), are common in patients with heart failure and reduced ejection fraction (HFrEF). In such patients, SDB is associated with increased cardiovascular morbidity and mortality but it remains uncertain whether treating SDB by adaptive servo-ventilation (ASV) in such patients ...
Zusammenfassung
Introduction Both types of sleep-disordered breathing (SDB), obstructive and central sleep apnoea (OSA and CSA, respectively), are common in patients with heart failure and reduced ejection fraction (HFrEF). In such patients, SDB is associated with increased cardiovascular morbidity and mortality but it remains uncertain whether treating SDB by adaptive servo-ventilation (ASV) in such patients reduces morbidity and mortality. Aim ADVENT-HF is designed to assess the effects of treating SDB with ASV on morbidity and mortality in patients with HFrEF. Methods ADVENT-HF is a multicentre, multinational, randomized, parallel-group, open-label trial with blinded assessment of endpoints of standard medical therapy for HFrEF alone vs. with the addition of ASV in patients with HFrEF and SDB. Patients with a history of HFrEF undergo echocardiography and polysomnography. Those with a left ventricular ejection fraction <= 45% and SDB (apnoea-hypopnoea index >= 15) are eligible. SDB is stratified into OSA with >= 50% of events obstructive or CSA with >50% of events central. Those with OSA must not have excessive daytime sleepiness (Epworth score of <= 10). Patients are then randomized to receive or not receive ASV. The primary outcome is the composite of all-cause mortality, cardiovascular hospital admissions, new-onset atrial fibrillation requiring anti-coagulation but not hospitalization, and delivery of an appropriate discharge from an implantable cardioverter-defibrillator not resulting in hospitalization during a maximum follow-up time of 5 years. Conclusion The ADVENT-HF trial will help to determine whether treating SDB by ASV in patients with HFrEF improves morbidity and mortality.
Metadaten zuletzt geändert: 25 Nov 2020 15:45