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Early postoperative tumor progression predicts clinical outcome in glioblastoma—implication for clinical trials

Merkel, Andreas ; Soeldner, Dorothea ; Wendl, Christina ; Urkan, Dilek ; Kuramatsu, Joji B. ; Seliger, Corinna ; Proescholdt, Martin ; Eyupoglu, Ilker Y. ; Hau, Peter ; Uhl, Martin


Molecular markers define the diagnosis of glioblastoma in the new WHO classification of 2016, challenging neuro-oncology centers to provide timely treatment initiation. The aim of this study was to determine whether a time delay to treatment initiation was accompanied by signs of early tumor progression in an MRI before the start of radiotherapy, and, if so, whether this influences the survival ...


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