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Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1

Persad, Patrice J., Heid, Iris M., Weeks, Daniel E. , Baird, Paul N., de Jong, Eiko K. , Haines, Jonathan L., Pericak-Vance, Margaret A. and Scott, William K. (2017) Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Investigative Opthalmology & Visual Science 58 (10), p. 4027.

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Other URL: http://doi.org/10.1167/iovs.17-21734


Abstract

PURPOSE. Presently; 52 independent nuclear single nucleotide polymorphisms (nSNPs) have been associated with age-related macular degeneration (AMD) but their effects do not explain all its variance. Genetic interactions between the nuclear and mitochondrial (mt) genome may unearth additional genetic loci previously unassociated with AMD risk. METHODS. joint effects of nSNPs and selected mtSNPs ...

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Item type:Article
Date:2017
Institutions:Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie
Identification Number:
ValueType
10.1167/iovs.17-21734DOI
Keywords:GENOME BROWSER; ASSOCIATION; MELANOCYTES; RLBP1; GENE; EXPRESSION; MUTATIONS; MELANOMA; CELLS; UCSC; age-related macular degeneration (AMD); genetics; risk; mitochondrial DNA; genome-wide interaction study (GWIS); joint effect
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39273
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