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An experimental and theoretical comparative study of the entrapment and release of dexamethasone from micellar and vesicular aggregates of PAMAM-PCL dendrimers

Avila-Salas, Fabián, Pereira, Alfredo, Rojas, Moisés A., Saavedra-Torres, Mario, Montecinos, Rodrigo, Bonardd, Sebastián , Quezada, Caterina, Saldías, Soledad, Díaz Díaz, David , Leiva, Angel, Radic, Deodato and Saldías, César (2017) An experimental and theoretical comparative study of the entrapment and release of dexamethasone from micellar and vesicular aggregates of PAMAM-PCL dendrimers. European Polymer Journal 93, pp. 507-520.

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Other URL: http://doi.org/10.1016/j.eurpolymj.2017.06.023


Abstract

Self-assembling dendrimers in aqueous solution have attracted many efforts focused on the rationalization and development of consistent strategies to design carriers that are useful in the field of drug release. In this way, amphiphilic dendrimers with specific structural features and self-assembling behaviors in aqueous media would enable drug entrapment as well as drug release over a determined ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. David Díaz Díaz
Identification Number:
ValueType
10.1016/j.eurpolymj.2017.06.023DOI
Keywords:DRUG-DELIVERY SYSTEMS; MOLECULAR-DYNAMICS SIMULATIONS; BLOCK-COPOLYMER; PNEUMOCOCCAL MENINGITIS; TERMINATED PAMAM; GENE DELIVERY; IN-SITU; VESICLES; NANOPARTICLES; CARRIER; Dendrimers; Aggregates; Free energy; Molecular dynamic simulation
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39293
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