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Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension

Wetzl, Veronika, Tiede, Svenja Lena, Faerber, Lothar, Weissmann, Norbert , Schermuly, Ralph Theo , Ghofrani, Hossein Ardeschir and Gall, Henning (2017) Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension. Lung 195 (4), pp. 489-496.

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Other URL: http://doi.org/10.1007/s00408-017-0014-5


Abstract

Purpose Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) are of particular interest in the remodeling processes of pulmonary hypertension. The aim of this study was to investigate MMP/TIMP ratios of selected biomarkers (MMP2, MMP9, TIMP1, TIMP4) at follow-up examination (V2) and their prognostic value in patients with idiopathic pulmonary arterial hypertension (iPAH). ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
10.1007/s00408-017-0014-5DOI
Keywords:ACUTE MYOCARDIAL-ISCHEMIA; MATRIX METALLOPROTEINASES; TISSUE INHIBITOR; REPERFUSION INJURY; SURVIVAL; MONOCROTALINE; BIOMARKERS; REGISTRY; INFLAMMATION; EXPRESSION; Heart failure [C14.280.434]; Hypertension pulmonary [C08.381.423]; Matrix metalloproteinases [D08.811.277.656.675.374.525]; Prognosis [E01.789]; Survival analysis [E05.318.740.998]
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39318
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