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Can a fibrotic liver afford epithelial-mesenchymal transition?

Munker, Stefan, Wu, Yong-Le, Ding, Hui-Guo, Liebe, Roman and Weng, Hong-Lei (2017) Can a fibrotic liver afford epithelial-mesenchymal transition? World Journal of Gastroenterology 23 (26), p. 4661.

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Other URL: http://doi.org/10.3748/wjg.v23.i26.4661


Abstract

The question whether epithelial-mesenchymal transition (EMT) occurs during liver fibrogenesis is a controversial issue. In vitro studies confirm that hepatocytes or cholangiocytes undergo EMT upon transforming growth factor beta (TGF-beta) stimulation, whereas in vivo experiments based on genetic fate mapping of specific cell populations suggest that EMT does not occur in fibrotic animal models. ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.3748/wjg.v23.i26.4661DOI
Keywords:GROWTH-FACTOR-BETA; TGF-BETA; PARENCHYMAL EXTINCTION; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; HUMAN CIRRHOSIS; STELLATE CELL; ADULT LIVER; FIBROSIS; HEPATOCYTES; Epithelial-mesenchymal transition; Liver fibrosis; Liver cirrhosis; Transforming growth factor-beta
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39367
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