Munker, Stefan, Wu, Yong-Le, Ding, Hui-Guo, Liebe, Roman and Weng, Hong-Lei (2017) Can a fibrotic liver afford epithelial-mesenchymal transition? World Journal of Gastroenterology 23 (26), p. 4661.
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Other URL: http://doi.org/10.3748/wjg.v23.i26.4661
Abstract
The question whether epithelial-mesenchymal transition (EMT) occurs during liver fibrogenesis is a controversial issue. In vitro studies confirm that hepatocytes or cholangiocytes undergo EMT upon transforming growth factor beta (TGF-beta) stimulation, whereas in vivo experiments based on genetic fate mapping of specific cell populations suggest that EMT does not occur in fibrotic animal models. ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2017 | ||||
| Institutions: | Medicine > Lehrstuhl für Innere Medizin I | ||||
| Identification Number: |
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| Keywords: | GROWTH-FACTOR-BETA; TGF-BETA; PARENCHYMAL EXTINCTION; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; HUMAN CIRRHOSIS; STELLATE CELL; ADULT LIVER; FIBROSIS; HEPATOCYTES; Epithelial-mesenchymal transition; Liver fibrosis; Liver cirrhosis; Transforming growth factor-beta | ||||
| Dewey Decimal Classification: | 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 39367 |
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