Ciolek, Justyna ; Reinfrank, Helen ; Quinton, Loïc ; Viengchareun, Say ; Stura, Enrico A. ; Vera, Laura ; Sigismeau, Sabrina ; Mouillac, Bernard ; Orcel, Hélène ; Peigneur, Steve ; Tytgat, Jan ; Droctové, Laura ; Beau, Fabrice ; Nevoux, Jerome ; Lombès, Marc 
; Mourier, Gilles ; De Pauw, Edwin ; Servent, Denis ; Mendre, Christiane ; Witzgall, Ralph ; Gilles, Nicolas
; Mourier, Gilles ; De Pauw, Edwin ; Servent, Denis ; Mendre, Christiane ; Witzgall, Ralph ; Gilles, Nicolas 
Abstract
Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 ...
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