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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

Ciolek, Justyna ; Reinfrank, Helen ; Quinton, Loïc ; Viengchareun, Say ; Stura, Enrico A. ; Vera, Laura ; Sigismeau, Sabrina ; Mouillac, Bernard ; Orcel, Hélène ; Peigneur, Steve ; Tytgat, Jan ; Droctové, Laura ; Beau, Fabrice ; Nevoux, Jerome ; Lombès, Marc ; Mourier, Gilles ; De Pauw, Edwin ; Servent, Denis ; Mendre, Christiane ; Witzgall, Ralph ; Gilles, Nicolas


Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 ...


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