Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico A., Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc 
, Mourier, Gilles, De Pauw, Edwin , Servent, Denis , Mendre, Christiane, Witzgall, Ralph and Gilles, Nicolas
(2017)
Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Proceedings of the National Academy of Sciences 114 (27), pp. 7154-7159.
Full text not available from this repository.
Other URL: http://doi.org/10.1073/pnas.1620454114
Abstract
Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2017 | ||||
| Institutions: | Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Ralph Witzgall | ||||
| Identification Number: |
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| Keywords: | KUNITZ-TYPE PROTEASE; MUSCARINIC TOXINS; ALPHA-DENDROTOXIN; TRYPSIN-INHIBITOR; CRYSTAL-STRUCTURE; HIGH-AFFINITY; CYST GROWTH; ANTAGONIST; VENOM; ALPHA(1A)-ADRENOCEPTOR; polycystic kidney disease; Kunitz peptide; snake toxin | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 39378 |
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