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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

Ciolek, Justyna, Reinfrank, Helen, Quinton, Loïc, Viengchareun, Say, Stura, Enrico A., Vera, Laura, Sigismeau, Sabrina, Mouillac, Bernard, Orcel, Hélène, Peigneur, Steve, Tytgat, Jan, Droctové, Laura, Beau, Fabrice, Nevoux, Jerome, Lombès, Marc , Mourier, Gilles, De Pauw, Edwin , Servent, Denis , Mendre, Christiane, Witzgall, Ralph and Gilles, Nicolas (2017) Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease. Proceedings of the National Academy of Sciences 114 (27), pp. 7154-7159.

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Other URL: http://doi.org/10.1073/pnas.1620454114


Abstract

Polycystic kidney diseases (PKDs) are genetic disorders that can cause renal failure and death in children and adults. Lowering cAMP in cystic tissues through the inhibition of the type-2 vasopressin receptor (V2R) constitutes a validated strategy to reduce disease progression. We identified a peptide from green mamba venom that exhibits nanomolar affinity for the V2R without any activity on 155 ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie > Prof. Dr. Ralph Witzgall
Identification Number:
ValueType
10.1073/pnas.1620454114DOI
Keywords:KUNITZ-TYPE PROTEASE; MUSCARINIC TOXINS; ALPHA-DENDROTOXIN; TRYPSIN-INHIBITOR; CRYSTAL-STRUCTURE; HIGH-AFFINITY; CYST GROWTH; ANTAGONIST; VENOM; ALPHA(1A)-ADRENOCEPTOR; polycystic kidney disease; Kunitz peptide; snake toxin
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39378
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