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Improved risk stratification in prevention by use of a panel of selected circulating microRNAs

Keller, Till ; Boeckel, Jes-Niels ; Groß, Stefan ; Klotsche, Jens ; Palapies, Lars ; Leistner, David ; Pieper, Lars ; Stalla, Günnter K. ; Lehnert, Hendrik ; Silber, Sigmund ; Pittrow, David ; Maerz, Winfried ; Dörr, Marcus ; Wittchen, Hans-Ulrich ; Baumeister, Sebastian E. ; Völker, Uwe ; Felix, Stephan B. ; Dimmeler, Stefanie ; Zeiher, Andreas M.



Abstract

Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 and miR-133 were determined from peripheral blood by qPCR and combined to a risk ...

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