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Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation

Weide, Thomas ; Vollenbröker, Beate ; Schulze, Ulf ; Djuric, Ivona ; Edeling, Maria ; Bonse, Jakob ; Hochapfel, Florian ; Panichkina, Olga ; Wennmann, Dirk-Oliver ; George, Britta ; Kim, Seonhee ; Daniel, Christoph ; Seggewiß, Jochen ; Amann, Kerstin ; Kriz, Wilhelm ; Krahn, Michael P. ; Pavenstädt, Hermann


The nephron is the basic physiologic subunit of the mammalian kidney and is made up of several apicobasally polarized epithelial cell types. The process of apicobasal polarization in animal cells is controlled by the evolutionarily conserved Crumbs (CRB), Partitioning-defective, and Scribble protein complexes. Here, we investigated the role of protein associated with LIN-7 1 (Pals1, also known as ...


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