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Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation

Weide, Thomas, Vollenbröker, Beate, Schulze, Ulf, Djuric, Ivona, Edeling, Maria, Bonse, Jakob, Hochapfel, Florian, Panichkina, Olga, Wennmann, Dirk-Oliver, George, Britta, Kim, Seonhee, Daniel, Christoph, Seggewiß, Jochen, Amann, Kerstin, Kriz, Wilhelm, Krahn, Michael P. and Pavenstädt, Hermann (2017) Pals1 Haploinsufficiency Results in Proteinuria and Cyst Formation. Journal of the American Society of Nephrology 28 (7), pp. 2093-2107.

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Other URL: http://doi.org/10.1681/ASN.2016040474


Abstract

The nephron is the basic physiologic subunit of the mammalian kidney and is made up of several apicobasally polarized epithelial cell types. The process of apicobasal polarization in animal cells is controlled by the evolutionarily conserved Crumbs (CRB), Partitioning-defective, and Scribble protein complexes. Here, we investigated the role of protein associated with LIN-7 1 (Pals1, also known as ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Molekulare und zelluläre Anatomie
Identification Number:
ValueType
10.1681/ASN.2016040474DOI
Keywords:MAMMALIAN EPITHELIAL-CELLS; HIPPO PATHWAY; POLARITY COMPLEXES; KIDNEY DEVELOPMENT; TIGHT JUNCTION; SLIT DIAPHRAGM; IN-VIVO; DROSOPHILA; CRUMBS; MORPHOGENESIS;
Dewey Decimal Classification:500 Science > 570 Life sciences
600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39416
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