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Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

Lauinger, Linda, Li, Jing, Shostak, Anton, Cemel, Ibrahim Avi, Ha, Nati, Zhang, Yaru, Merkl, Philipp E, Obermeyer, Simon, Stankovic-Valentin, Nicolas, Schafmeier, Tobias, Wever, Walter J, Bowers, Albert A, Carter, Kyle P, Palmer, Amy E, Tschochner, Herbert, Melchior, Frauke , Deshaies, Raymond J , Brunner, Michael and Diernfellner, Axel (2017) Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nature Chemical Biology 13 (7), pp. 709-714.

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Other URL: http://doi.org/10.1038/nchembio.2370


Abstract

Thiolutin is a disulfide-containing antibiotic and anti-angiogenic compound produced by Streptomyces. Its biological targets are not known. We show that reduced thiolutin is a zinc chelator that inhibits the JAB1/MPN/Mov34 (JAMM) domain-containing metalloprotease Rpn11, a deubiquitinating enzyme of the 19S proteasome. Thiolutin also inhibits the JAMM metalloproteases Csn5, the deneddylase of the ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie > Lehrstuhl für Biochemie III > Prof. Dr. Herbert Tschochner
Identification Number:
ValueType
10.1038/nchembio.2370DOI
Keywords:HISTONE H2A DEUBIQUITINASE; MESSENGER-RNA; TRANSCRIPTIONAL REGULATION; NEUROSPORA-CRASSA; RESISTANT MUTANTS; ESCHERICHIA-COLI; MULTIPLE-MYELOMA; CIRCADIAN CLOCK; HUMAN-CELLS; PROTEASOME;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39438
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